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Fine lines and wrinkles are some of the most persistent (and frustrating) signs of aging to treat. In a recent survey of more than 1,300 NewBeauty readers,* one serum emerged as a standout for softening these visible signs of aging and delivering a glass-like finish: SkinCeuticals P-Tiox ($148).
While many serums claim to firm and improve skin’s appearance, P-Tiox is being praised by users across age groups for actually delivering on those promises. “I’ve been using this at night for about two months now, and I can visibly see a difference in the deeper lines around my mouth and eyes,” shared one 60-year-old reader. Another, 29, noted a “major improvement in smile lines, forehead lines, and nasolabial folds” after just a few weeks. Others reported similar results within the first week, pointing to smoother texture, plumper skin and a more even tone.
What’s Inside: The Formula Behind the Results
So what makes P-Tiox different? The peptide-powered serum is inspired by the wrinkle-reducing effects of neurotoxin injections, but designed to be completely noninvasive.
At the core of the formula is an advanced peptide complex clinically shown to reduce the appearance of nine different types of expression lines. It’s supported by a trio of high-performance ingredients that target multiple signs of aging: 5 percent PHA to smooth and refine texture, 5 percent niacinamide to even tone and strengthen the skin barrier, and 1 percent laminaria extract, a marine-derived ingredient known for its soothing and hydrating properties.
The formula is also physician-tested to complement neurotoxin injections but is equally effective on its own, offering a needle-free alternative for visible wrinkle improvement.
Visible Results Fast
Across the board, users reported noticeable improvements in skin texture, tone, and fine lines—often in less time than expected.
One 46-year-old reviewer noted, “This is the only serum that has truly helped my fine lines and wrinkles. Over a few weeks, I have found my wrinkles and fine lines to be improved as well as redness and skin tone issues. It has completely surpassed other serum efficacy in my opinion.”
Another user noted the serum made “skin look glassy and evened out skin texture. Saw results in a few weeks. No side effects for me,” they noted.
Several users also reported that it helped prolong the effects of their neurotoxin injections, making it a smart addition to both professional and at-home routines.
The Bonus Benefits
What makes P-Tiox even more compelling is its multitasking nature. Many users noticed more than just wrinkle reduction—think refined texture, improved hydration, and a radiant, youthful finish.
“Softens contraction lines and gives glass skin radiance,” noted a 54-year-old reviewer. “My pores are smaller, and my skin is more hydrated and plump,” said a 38-year-old after just a week of use. “I cannot live without this product now.”
Importantly, users also reported no irritation or negative side effects—just smooth, even, radiant skin.
*Source: BeautyEngine Advanced Research, 2025
